Research topics

The role of estradiol-induced microRNAs in the pathogenesis of endometrial cancer

Klaudia Klicka

Endometrial cancer is one of the most common cancers of the reproductive organs in women. Endometrial cancer is divided into two types. Type I is estrogen-dependent endometrioid adenocarcinoma, while type II is usually serous carcinoma. Despite the documented role of estrogens in the pathogenesis of endometrial cancer, the molecular mechanism of action of these hormones is still poorly understood. In our study of the pathogenesis of this disease, we focus on the role of microRNA molecules whose expression is induced by estradiol in endometrial cancer cells.

Investigating the efficacy of N-acetylcysteine in surgical and chronic wound healing, including a diabetic model

Albert Stachura and Wiktor Paskal

N-acetylcysteine (NAC) is an antioxidant and a drug used in daily clinical practice. Literature data and previous experience of our team show beneficial effect of NAC on wound healing. We have demonstrated such effects on surgical wound healing when skin was pretreated with topically administered NAC. We are currently continuing in vivo studies (in a db/db mouse model) determining the efficacy of NAC in the treatment of diabetic wounds.

Development of techniques for automated histomorphometric analysis of peripheral nerve sections

Michał Kopka and Wiktor Paskal

Histomorphometric analysis of peripheral nerves is one of the fundamentals of nerve regeneration evaluation in experimental studies in vivo and in clinical dignostics.The analysis performed in a classical way, by a trained diagnostician, is fraught with the risk of error because it is limited to the evaluation of a fragment of a full section of the nerve, in which even several thousand fibers run. Our team is working on automating this method by developing computer algorithms for histomorphometric measurements.

Biological brachytherapy

Wiktor Paskal

Biological brachytherapy is a fairly new concept in the development of experimental therapies that use biological vectors - viruses, cells, genetic material transduction systems - to modify tissues or combat underlying diseases. In our study, we modify mesenchymal stem cells isolated from adipose tissue (ADSCs) and inject them into tissue flaps to study their local effects on a region of the body.

Eye-tracking in the study of self-esteem of patients undergoing reconstructive surgery

Wiktor Paskal, Albert Stachura, Michał Kopka, Adriana Paskal, Piotr Pietruski

Eye tracking is an objective source of information regarding the relevance of objects viewed by the examined person. These points of interest are often unconsciously selected by the brain. Eye-tracking, a testing method that allows the registration of objects on which the examined person focuses his gaze, is used by us in the objective assessment of the subjective relevance of anatomical points of the body. This is an extremely important premise for surgeons, whose procedures have an obvious impact on the patient's self-esteem. Our team conducts eye-tracking analyses of the perception of various body regions in a healthy population of non-professionals, professionals, and individuals who may have self-perception disorders.

Effect of adipose tissue stem cells (ADSC) on scar formation